abstract：INTRODUCTION:Infantile hemangiomas (IH) are the most common benign vascular tumors of childhood, with an incidence of 5-10% during the first year of age. Propranolol is considered the first-line treatment for this condition. Potentially there is a high probability of negative results to therapy, because in many countri...

journal_title：Advances in therapy

authors： Castaneda S,Melendez-Lopez S,Garcia E,De la Cruz H,Sanchez-Palacio J

更新日期：2016-10-01 00:00:00

abstract：:In order for the global healthcare system to remain sustainable, healthcare spending needs to be reduced, and self-treating certain conditions under the guidance of a pharmacist provides a means of accomplishing this goal. This article was developed to describe global healthcare trends affecting self-care with a speci...

journal_title：Advances in therapy

authors： Bell J,Dziekan G,Pollack C,Mahachai V

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in p...

journal_title：Advances in therapy

authors： Baltzis D,Roustit M,Grammatikopoulou MG,Katsaboukas D,Athanasiou V,Iakovou I,Veves A,Manes C,Trakatelli MC

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Wet age-related macular degeneration (AMD) is a chronic eye condition that causes severe deterioration of vision and even blindness. Current wet AMD treatment in the UK involves the vascular endothelial growth factor inhibitors ranibizumab and aflibercept. Patients with wet AMD require frequent and long-te...

journal_title：Advances in therapy

authors： Ghosh W,Wickstead R,Claxton L,Kusel J,Taylor M,Fleetwood K,Pulikottil-Jacob R

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:This clinical study aimed to investigate the effect of brinzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelial cells (CECs) in patients with glaucoma using a follow-up clinical study design. METHODS:Patients with primary open-angle glaucoma or ocular hypertension were administrated an...

journal_title：Advances in therapy

authors： Nakano T,Inoue R,Kimura T,Suzumura H,Tanino T,Yamazaki Y,Yoshikawa K,Tatemichi M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The OPTIMA© (MSD, Courbevoie, France) questionnaire was developed to promote shared decisions and the set-up of specific micro-objectives in clinical practice by optimizing communication between type 2 diabetes (T2DM) patients and their physicians. The present study aimed to assess OPTIMA in clinical practic...

journal_title：Advances in therapy

authors： Grimaldi A,Penfornis A,Consoli S,Falissard B,Eymard E,Williams P,Dejager S

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Oxycodone is one of the most commonly used opioid analgesics in the clinical management of pain. The present retrospective analysis aimed to determine the dose of oxycodone that could achieve effective control of moderate pain when combined with a fixed dose of acetaminophen, and the time required to reach...

journal_title：Advances in therapy

authors： Natoli S,Lazzari M,Carpenedo R,Palombo E,Silvi MB,Mammucari M,Dauri M

更新日期：2016-06-01 00:00:00

abstract：:Endophthalmitis is an intraocular inflammatory condition which may or may not be caused by infective agents. Noninfectious (sterile) endophthalmitis may be attributable to various causes including postoperative retained soft lens matter or toxicity following introduction of other agents into the eye. Infectious endoph...

journal_title：Advances in therapy

authors： Tranos P,Dervenis N,Vakalis AN,Asteriadis S,Stavrakas P,Konstas AG

更新日期：2016-05-01 00:00:00

abstract：:Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to...

journal_title：Advances in therapy

authors： Coca-Pelaz A,Barnes L,Rinaldo A,Cardesa A,Shah JP,Rodrigo JP,Suárez C,Eloy JA,Bishop JA,Devaney KO,Thompson LD,Wenig BM,Strojan P,Hamoir M,Bradley PJ,Gnepp DR,Silver CE,Slootweg PJ,Triantafyllou A,Vander Poorten V,

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:This Phase 2 clinical trial assessed the efficacy and safety of the novel antioxidative, renewable compound SkQ1 for topical treatment of dry eye signs and symptoms. METHODS:In a single-center, randomized, double-masked, placebo-controlled, 29-day study, 91 subjects with mild to moderate dry eye instilled...

journal_title：Advances in therapy

authors： Petrov A,Perekhvatova N,Skulachev M,Stein L,Ousler G

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:High-dose intravenous esomeprazole is the only approved pharmacological treatment for the prevention of peptic ulcer rebleeding (currently approved in over 100 countries worldwide), but has not yet been approved in China. This study aimed to evaluate a high-dose esomeprazole intravenous regimen vs. an acti...

journal_title：Advances in therapy

authors： Bai Y,Chen DF,Wang RQ,Chen YX,Shi RH,Tian DA,Chen H,Eklund S,Li ZS,Chinese Peptic Ulcer Bleeding Research Group.

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a complex disease in which multiple organs and hormones contribute to the pathogenesis of disease. The intestinal hormone, glucagon-like peptide-1 (GLP-1), secreted in response to nutrient ingestion, increases insulin secretion from pancreatic β-cells and reduces glucagon...

journal_title：Advances in therapy

authors： Jain R

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Ivabradine has opened up new possibilities for treating stable angina and chronic heart failure by lowering heart rate. Ivabradine lowers heart rate by selectively inhibiting the I f current in the sinoatrial node. This study aimed to determine whether the decrease in heart rate achieved with ivabradine wa...

journal_title：Advances in therapy

authors： Jedlickova L,Merkovska L,Jackova L,Janicko M,Fedacko J,Novakova B,Chmelarova A,Majernik J,Pella D

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Diuretic responsiveness in patients with chronic heart failure (CHF) is better assessed by urine production per unit diuretic dose than by the absolute urine output or diuretic dose. Diuretic resistance arises over time when the plateau rate of sodium and water excretion is reached prior to optimal fluid e...

journal_title：Advances in therapy

authors： Paterna S,Di Gaudio F,La Rocca V,Balistreri F,Greco M,Torres D,Lupo U,Rizzo G,di Pasquale P,Indelicato S,Cuttitta F,Butler J,Parrinello G

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to investigate whether the efficacy of liraglutide observed in randomized controlled trials translates into therapeutic benefits in the French population during routine clinical practice. METHODS:This observational, prospective, multicenter study included 3152 adults with type 2 ...

journal_title：Advances in therapy

authors： Gautier JF,Martinez L,Penfornis A,Eschwège E,Charpentier G,Huret B,Madani S,Gourdy P

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Advanced renal cell carcinoma (RCC) shows a propensity for extending into the tributaries of the renal veins, which poses a notable surgical challenge. In this study we addressed the question as to whether patients with RCC and vein involvement can be identified as having a significant risk of immediate de...

journal_title：Advances in therapy

authors： Akkoyun M,Merseburger AS,Kramer MW,Herrmann TR,Kuczyk MA,von Klot CA

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Diabetes-related healthcare costs are increasing in the United States, with inpatient hospitalization the largest component of medical expenditures. The aims of this study were to characterize hospitalized type 2 diabetes mellitus (T2DM) patients, understand the relationship between hospitalization and hea...

journal_title：Advances in therapy

authors： Saundankar V,Ellis J,Allen E,DeLuzio T,Moretz C,Meah Y,Suehs B,Bouchard J

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:The present study aimed to identify preoperative factors that predispose the development of subretinal fluid (SRF) following successful macular hole (MH) surgery. METHODS:Thirty-four eyes of 33 consecutive patients that underwent pars plana vitrectomy for idiopathic full-thickness MH surgery were included...

journal_title：Advances in therapy

authors： Tranos PG,Stavrakas P,Vakalis AN,Asteriadis S,Lokovitis E,Konstas AG

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:A combination of magnetic resonance imaging (MRI) with real-time high-resolution ultrasound (US) known as fusion imaging may improve visualization of musculoskeletal (MSK) sports medicine injuries. The aim of this study was to evaluate the applicability of MRI-US fusion technology in MSK sports medicine. ...

journal_title：Advances in therapy

authors： Wong-On M,Til-Pérez L,Balius R

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:New inhalers propelled by hydrofluoroalkanes (HFAs) have improved plume characteristics: higher fine particle fraction, and warmer plumes with reduced force and velocity. Together, this may avoid reflex interruption of inhalation and improve lung deposition of the inhaled drugs. However, even with HFA-prop...

journal_title：Advances in therapy

authors： Johal B,Murphy S,Tuohy J,Marshall J

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Adherence to diabetes medication has been linked to improved glycemic levels and lower costs, but previous research on adherence has typically involved oral antidiabetic medication or insulin. This study examines how adherence and persistence to once-daily liraglutide impact glycemic control and economic o...

journal_title：Advances in therapy

authors： Buysman EK,Liu F,Hammer M,Langer J

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:The 21-gene breast cancer assay (Oncotype DX(®); Genomic Health, Inc.) is a validated diagnostic test that predicts the likelihood of adjuvant chemotherapy benefit and 10-year risk of distant recurrence in patients with hormone-receptor-positive, human epidermal growth receptor 2-negative, early-stage brea...

journal_title：Advances in therapy

authors： Bargalló-Rocha JE,Lara-Medina F,Pérez-Sánchez V,Vázquez-Romo R,Villarreal-Garza C,Martínez-Said H,Shaw-Dulin RJ,Mohar-Betancourt A,Hunt B,Plun-Favreau J,Valentine WJ

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Respiratory tract infections are common, and these infections occur frequently in children, susceptible adults, and older persons. The risk for recurrences and complications relates not only to the presence of viruses but also to immune function. Therefore, modulation of the immune system and antiviral int...

journal_title：Advances in therapy

authors： Schapowal A,Klein P,Johnston SL

更新日期：2015-03-01 00:00:00

abstract：:There has been increased interest in gout in both academic and clinical practice settings. Several reasons may explain this. The prevalence of both hyperuricemia and gout has risen in the last decades in developed countries and therefore the burden of gout has increased. The association of hyperuricemia and gout with ...

journal_title：Advances in therapy

authors： Perez-Ruiz F,Dalbeth N,Bardin T

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Fixed-combination intraocular pressure (IOP)-lowering medications simplify treatment regimens for patients requiring 2 ocular hypotensive agents to maintain sufficiently low IOP. The aim of this study was to evaluate the safety and efficacy of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) versu...

journal_title：Advances in therapy

authors： Gandolfi SA,Lim J,Sanseau AC,Parra Restrepo JC,Hamacher T

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Liraglutide has been widely used in the treatment of type 2 diabetes mellitus (T2DM), however, the results of a number of randomized placebo-controlled trials on the effects of liraglutide for the treatment of T2DM have varied. The purpose of this study was to assess the effects of liraglutide versus place...

journal_title：Advances in therapy

authors： Du Q,Wang YJ,Yang S,Zhao YY,Han P

更新日期：2014-11-01 00:00:00

abstract：:Diabetic foot ulcers (DFUs) are one of the most common and serious complications of diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a dynamic and complex biological process that can be divided into four partly overlapping phases: hemostasis, inflammation, proliferative and remode...

journal_title：Advances in therapy

authors： Baltzis D,Eleftheriadou I,Veves A

更新日期：2014-08-01 00:00:00

abstract：:The prognosis for patients with rheumatoid arthritis or spondyloarthritides has improved dramatically due to earlier diagnosis, recognition of the need to treat early with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), alone or in combinations, the establishment of treatment targets, and the ...

journal_title：Advances in therapy

authors： Govoni M,Bortoluzzi A,Lo Monaco A,Adami S,Addimanda O,Caimmi C,De Vita S,Ferri C,Manfredi A,Orsolini G,Possemato N,Quartuccio L,Salvarani C,Zabotti A,Rossini M

更新日期：2014-08-01 00:00:00

abstract：:Multiple, potentially practice-changing cardiology trials have been presented or published over the past year. In this paper, we summarize and place in clinical context, new data regarding management of acute coronary syndrome and ST-elevation myocardial infarction (copeptin assessment, otamixaban, cangrelor, prasugre...

journal_title：Advances in therapy

authors： McNeice AH,McAleavey NM,Menown IB

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:To compare the 24-h intraocular pressure (IOP) control and tolerability of travoprost/timolol benzalkonium chloride (BAK)-free (TTFC) vs. latanoprost/timolol fixed combination preserved with BAK (LTFC) in open-angle glaucoma patients insufficiently controlled with latanoprost 0.005% monotherapy given once ...

journal_title：Advances in therapy

authors： Konstas AG,Voudouragkaki IC,Boboridis KG,Haidich AB,Paschalinou E,Giannopoulos T,Dragoumis ND,Makridis AK,Kahook MY

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

journal_title：Advances in therapy

authors： Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS:The IMS LifeLink Health Plan Claims database was use...

journal_title：Advances in therapy

authors： Yeaw J,Watson C,Fox KM,Schabert VF,Goodman S,Gandra SR

更新日期：2014-04-01 00:00:00

abstract：:Treating hyperglycemia is a critical aspect of managing type 2 diabetes mellitus (T2DM), but can be especially challenging in patients from vulnerable groups such as those with chronic kidney disease, African Americans, and older people. The dipeptidyl peptidase (DPP)-4 inhibitors are relatively new oral antidiabetes ...

journal_title：Advances in therapy

authors： Kountz D

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Sevelamer hydrochloride (SH) and lanthanum carbonate (LC) are calcium-free phosphate binders used for the management of hyperphosphatemia in patients with end-stage renal disease (ESRD). The objective of this analysis was to evaluate the real-world dose-relativity between SH and LC monotherapy in US patien...

journal_title：Advances in therapy

authors： Wilson RJ,Keith MS,Preston P,Copley JB

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. AFFIRM (Aran...

journal_title：Advances in therapy

authors： Choi P,Farouk M,Manamley N,Addison J

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control. METHODS:A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All pat...

journal_title：Advances in therapy

authors： Nakatani Y,Matsumura M,Monden T,Aso Y,Nakamoto T

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Naproxen is an NSAID with documented efficacy in pain management; however, it is associated with serious dose-related adverse events. A lower-dose naproxen drug product with comparable efficacy to commercially available naproxen could address these concerns. We studied the efficacy and safety of naproxen sub...

journal_title：Advances in therapy

authors： Young CL,Strand V,Altman R,Daniels S

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:ARTOS was an international, prospective, non-interventional, non-controlled observational study designed to determine the effectiveness, safety, and tolerability of moxifloxacin under daily-life conditions in patients with complicated skin and skin structure infections (cSSSIs) treated in Europe, the Middl...

journal_title：Advances in therapy

authors： Bogner JR,Kutaiman A,Esguerra-Alcalen M,Heldner S,Arvis P

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHO...

journal_title：Advances in therapy

authors： Arai T

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is associated with poor prognosis despite significant recent advances in its treatment. An intravenous formulation of epoprostenol sodium containing glycine and mannitol (epoprostenol GM; GlaxoSmithKline, London, UK) is widely used to treat PAH. A new formulation of ep...

journal_title：Advances in therapy

authors： Tamura Y,Ono T,Fukuda K,Satoh T,Sasayama S

更新日期：2013-05-01 00:00:00